吲哚胺2,3-双加氧酶
蜕膜
免疫系统
滋养层
胎儿
病态的
怀孕
生物
蜕膜细胞
免疫耐受
子痫前期
免疫学
内科学
医学
胎盘
色氨酸
氨基酸
生物化学
遗传学
作者
Ruiqi Chang,Da‐Jin Li,Ming‐Qing Li
摘要
The survival of allogeneic fetus during pregnancy contradicts the laws of immune responses. Behind this paradoxical phenomenon, the mechanism is quite complex. Indoleamine‐2,3‐dioxygenase ( IDO ) is the first and rate‐limiting enzyme of tryptophan catabolism. Emerging evidence shows that IDO is expressed at the maternal‐fetal interface, including trophoblast cells, decidual stroma cells, decidual immune cells (eg, natural killer cells, T cells, and macrophages), and vascular endothelial cells of decidua and chorion. Moreover, the expression and activity of IDO are different among non‐pregnant, normal pregnant, and pathological pregnant conditions. IDO plays important roles in normal pregnancy through immune suppression and regulation of fetal invasion and circulation. However, the abnormal expression and dysfunction of IDO are associated with some pathological pregnancies (including recurrent spontaneous abortion, preeclampsia, preterm labor, and fetal growth restriction).
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