菊粉
结直肠癌
药物输送
双歧杆菌
化学
长双歧杆菌
输送系统
药理学
谷胱甘肽
体外
医学
癌症研究
生物化学
癌症
内科学
乳酸菌
酶
有机化学
发酵
作者
Dongdong Wang,Feifei Sun,Chunbo Lu,Peng Chen,Zhaojie Wang,Yuanhao Qiu,Haibo Mu,Ze‐Hong Miao,Jinyou Duan
标识
DOI:10.1016/j.ijbiomac.2018.01.071
摘要
Colorectal cancer is one of the most common types of tumor in the world. Here we developed a lipoic acid esterified polysaccharide (inulin) delivery system for tanshinone IIA to treat colorectal cancer in vitro. The release of tanshinone IIA in the system was highly responsive to glutathione, which is commonly abundant in cancer cells. In addition, this drug delivery system was proliferative to Bifidobacterium longum, the common inhabitant of human intestine. Thus, this strategy might be useful to improve colon cancer therapy efficacy of anticancer drugs and meanwhile promote the growth of beneficial commensal flora in the gut.
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