医学
水痘带状疱疹病毒
免疫学
CD8型
类风湿性关节炎
入射(几何)
红斑狼疮
T细胞
病毒
抗原
抗体
免疫系统
光学
物理
作者
Hyung-Bae Park,Ki-Chan Kim,Jaehong Park,Tae Goo Kang,Hye‐Soon Lee,Tae‐Hwan Kim,Jae‐Bum Jun,Sang‐Cheol Bae,Dae-Hyun Yoo,Joe Craft,Sung‐Soo Jung
出处
期刊:PubMed
日期:2004-11-01
卷期号:31 (11): 2151-5
被引量:17
摘要
To examine whether the high incidence of herpes zoster in patients with systemic lupus erythematosus (SLE) is associated with the frequency of memory T cells specific to varicella zoster virus (VZV).Whole blood samples from 47 subjects [24 patients with SLE, 11 with rheumatoid arthritis (RA) as a disease control, and 12 healthy negative controls] were stimulated with VZV antigen, stained for surface CD4 and CD8 and intracellularly stained for the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin 4 (IL-4), and IL-10, followed by flow cytometry analyses. Correlations of VZV-specific T cell frequencies with the clinical status of patients were analyzed.Percentage of IFN-gamma-positive CD4 T cells was significantly lower in patients with SLE (0.043 +/- 0.009%) than in RA (0.102 +/- 0.019%) and healthy controls (0.126 +/- 0.025%) upon VZV stimulation. A similar pattern was seen in TNF-alpha-positive CD4 T cell responses. These low frequencies of VZV-specific CD4 T cells in patients with SLE were significantly related with disease activity (r = -0.435, p = 0.043).These data suggest that the high incidence of herpes zoster in patients with SLE was related to the intrinsic defects in controlling VZV reactivation, and thus VZV-specific CD4 T cell frequency could be another practical risk factor of herpes zoster in patients with SLE.
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