Versatile Ce(III)‐Terephthalic Acid@Au Metal Organic Frameworks for ROS Elimination and Photothermal Sterilization

Abstract Nanozymes have been widely used for treating reactive oxygen species (ROS) caused diseases. However, the ROS‐dependent antibacterial property is inevitably damaged during the process of scavenging ROS, which is unfavorable for the treatment of diseases related to both ROS accumulation and bacterial infections. To address the issues, biomedical materials with both ROS‐elimination ability and ROS‐independent antibacterial capacity are fabricated via in situ depositing spherical Au nanoparticles (Au NPs) on rough surface of metal organic frameworks composed of Ce(III) and terephthalic acid (Ce‐BDC@Au MOFs). The synthesized Ce‐BDC@Au MOFs show multi‐enzymatic activities owing to the reversible conversion between Ce 3+ and Ce 4+ , and can significantly scavenge ROS in cells. The deposition of spherical Au NPs on surface of Ce‐BDC MOFs causes Au NPs to come close proximity for forming plasmon resonance coupling, inducing the resonance wavelength of Au NPs red shifted to NIR region. Based on this, Ce‐BDC@Au MOFs show good photothermal conversion efficiency under NIR laser (808 nm) irradiation. Benefitting from rough surface and photothermal conversion ability, Ce‐BDC@Au MOFs have high antibacterial efficiency against staphylococcus aureus through both mechanically damaging and photothermal destruction. This strategy is biosafety and effectiveness for treating diseases related to both ROS accumulation and bacterial infections.