生物
竞争性内源性RNA
小RNA
假基因
小核仁RNA
机制(生物学)
生物信息学
多囊卵巢
女性生殖系统
计算生物学
长非编码RNA
非编码RNA
基因
核糖核酸
遗传学
内分泌学
基因组
哲学
胰岛素抵抗
胰岛素
认识论
作者
Yuxin Yang,Yi-Yi Xiong,Zezheng Pan
标识
DOI:10.1093/biolre/ioac200
摘要
The molecular mechanism of non-tumor female reproductive diseases is complicated and needs to be further elucidated. Recently, increasing evidence indicates that non-coding RNAs(ncRNAs) which are extremely rich in the female reproductive system are crucial factors in the pathogenesis of some female reproductive disorders. In fact, these ncRNAs such as lncRNAs, circRNAs, snoRNAs, and pseudogenes that share the same miRNA response elements (MREs) with mRNAs could compete for miRNA binding site to regulate gene expression, this phenomenon is known as the competing endogenous RNAs(ceRNAs) mechanism. This review aims to summarize the role of ceRNAs in cell proliferation, apoptosis, migration, and invasion of non-tumor female reproductive diseases such as polycystic ovary syndrome (PCOS), premature ovarian failure (POF), pre-eclampsia (PE), recurrent implantation failure (RIF), recurrent spontaneous abortion (RSA), endometriosis (EM), and endometritis, and list ceRNAs regulatory axes as well as downstream related signaling pathway. Additionally, based on certain ncRNAs that have already been proven to exist at differential levels in patient tissue samples, we also generalize some ncRNAs that can be used as potential biomarkers and therapeutic targets for these diseases in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI