炎症体
启动(农业)
炎症
免疫学
免疫
转录因子
生物
细胞生物学
医学
神经科学
免疫系统
遗传学
基因
植物
发芽
作者
R.K. Subbarao Malireddi,Thirumala‐Devi Kanneganti
标识
DOI:10.1016/j.it.2022.10.007
摘要
NLRP3 inflammasome regulation is essential for controlling cell death and inflammation. Mechanistic studies in murine cells suggest a two-step model of priming and activation with an indispensable role for NEK7. However, in a recent article in Immunity, Schmacke et al. report that, in humans, transcription-independent NLRP3 activation occurs by circumventing NEK7 via IKKβ.
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