Abstract This study evaluates the potential of muon tomography as a non-invasive technique for detecting concealed illicit drugs in cargo, based on detailed simulations performed using the GEANT4 toolkit. A combined analysis of muon scattering and absorption data was employed to enhance material discrimination, with a focus on realistic smuggling scenarios involving cocaine hidden within legitimate cargo. A two-stage inspection protocol is proposed to balance detection speed and resolution. In the first stage, a rapid scan lasting ≈ 60 seconds is used to identify anomalous scattering and absorption rates, without requiring full tomographic reconstruction. Upon detection of anomalies, an extended scan ≈ 30 minutes is initiated to enable high-resolution three-dimensional imaging for accurate localization and identification of hidden materials. Simulation results demonstrate that, with a detector spatial resolution of 1 mm (FWHM), concealed contraband such as cocaine can be detected with approximately 3 σ statistical significance during the rapid scan phase. In extended scans, cocaine packages concealed within banana boxes were successfully visualized and automatically identified using clustering algorithms such as DBSCAN applied to the tomographic reconstruction. These findings confirm the feasibility of cosmic-ray muon tomography as a passive, safe, and effective approach for contraband detection in real-world cargo inspection applications.