刺
干扰素基因刺激剂
癌症免疫疗法
免疫疗法
促炎细胞因子
免疫系统
医学
癌症研究
免疫学
先天免疫系统
炎症
工程类
航空航天工程
作者
Xianghui Li,Haoran Wang,Yuanyuan Chen,Zhiyan Li,Song Liu,Wenxian Guan,Youkun Lin,Cunwei Cao,Weitao Zheng,Jinhui Wu
出处
期刊:Acta Materia Medica
[Compuscript, Ltd.]
日期:2023-01-01
卷期号:2 (3)
被引量:2
标识
DOI:10.15212/amm-2023-0023
摘要
Activation of simulator of interferon genes (STING), which induces the production of proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules’ rapid degradation, restriction to tumor sites, insufficient intracellular concentrations, and low responsivity. Well-designed, multifunctional nano-formulations have emerged as optimized platforms for STING activation. Recently, a variety of nano-formulations have been developed and used in STING activation, thus facilitating immunotherapy in preclinical and clinical stages. Herein, we summarize recent advances in nanotechnology-based delivery, activation, and application strategies, which have advanced various aspects of immunotherapy. Novel STING agonists and their mechanisms in STING-activation-mediated tumor interventions are highlighted herein, to provide a comprehensive overview and discuss future directions for boosting immunotherapy via STING regulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI