Ambient‐Temperature, Metal‐Free, CDI‐Mediated Ex‐Situ Conversion of Acids to Amides: A Useful Late‐Stage Strategy

Abstract An efficient ex‐situ method for the amidation of carboxylic acids mediated by CDI has been disclosed herewith. This metal‐free strategy is performed at ambient temperature and can be applied effectively for late‐stage modification of amino acids and APIs.