Enhanced electrochemical detection of sorafenib, an anticancer drug via CoGd-LDH modified glassy carbon electrode

An electrochemical sensor based on well-formed nanorods like cobalt gadolinium layered double hydroxide (CoGd-LDH) was used as an electrocatalyst for the detection of anti-cancer drug sorafenib (SNb). CoGd-LDH were synthesized via coprecipitation and subsequent aging without the addition of surfactants. Using their improved capabilities, a new electrochemical SNb sensor was created by drop-coating CoGd-LDH on glassy carbon electrode (GCE). Electrochemical investigations revealed that CoGd-LDH/GCE had superior electrocatalytic performance for SNb detection, with a broad linear range with good correlation coefficient (0.11–5.22 ng/mL; R2 =0.9922 and 6.39–34.86 ng/mL, R2 =0.9944), limit of detection (0.09 and 0.55 ng/mL), and sensitivity (0.87 μA/μM cm2). In addition, the CoGd-LDH/GCE showed good reproducibility, acceptable cyclic and storage stability, repeatability, and interference ability with possible interfering species. Practical application of CoGd-LDH/GCE sensor for SNb detection in serum samples achieved satisfactory recovery, indicating enormous potential for quantitative detection of SNb in a variety of fields.