Isolated Metal Centers Activate Small Molecule Electrooxidation: Mechanisms and Applications

orbital and reduce the overly strong adsorption of CO on ensemble metal sites, which resolve the CO poisoning problems in most small molecules electro-oxidation reactions and thus improve catalytic stability. Based on these advantages of IASCs in the fields of electrochemical oxidation of small molecules, this review summarizes recent developments and advancements in IASCs in small molecules electro-oxidation reactions, focusing on anodic HOR in fuel cells and OER in electrolytic cells as well as their alternative reactions, such as formic acid/methanol/ethanol/glycerol/urea/5-hydroxymethylfurfural (HMF) oxidation reactions as key reactions. The catalytic merits of different oxidation reactions and the decoding of structure-activity relationships are specifically discussed to guide the precise design and structural regulation of IASCs from the perspective of a comprehensive reaction mechanism. Finally, future prospects and challenges are put forward, aiming to motivate more application possibilities for diverse functional IASCs.