Exosomes and exosomal miRNAs mediate the beneficial effects of exercise in ischemic stroke

Abstract Ischemic stroke is an acute cerebrovascular disease that is one of the leading causes of death and neurological disorders worldwide. Exosomes are a novel class of intercellular signaling regulators containing cell-specific proteins, lipids, and nucleic acids that transmit messages between cells and tissues. MicroRNAs are regulatory non-coding ribonucleic acids that are usually present in exosomes as signaling molecules. Studies have shown that exosomes and exosomal microRNAs can improve the prognosis of ischemic stroke by inhibiting the inflammatory response, reducing apoptosis, improving the imbalance of oxidative and antioxidant systems, and regulating cellular autophagy, among other processes. Previous studies have shown that exercise training can exert neuroprotective effects on ischemic stroke by promoting the release of exosomes and regulating the expression of exosomal microRNAs, which in turn regulate multiple signaling pathways. Exosomes and exosomal microRNAs may be key targets for exercise to promote cerebrovascular health. Therefore, the study of exercise-mediated exosomes and their microRNAs may provide new perspectives for exploring the mechanism of exercise intervention in the prevention and treatment of ischemic stroke.