Risperidone Powder Prepared by Spray Drying Technology for Intranasal Delivery

The main objective of this study was to prepare Risperidone (RIS) nasal powder by spray drying method, so as to achieve controlled drug release and high deposition efficiency in the nasal cavity. The microparticles with uniform size and controllable structure were prepared by mixing hydroxypropyl -βcyclodextrin (CD) with API before a novel microfluidic spray drying technology. The properties of particles were characterized in terms of particle size, crystal shape and in vitro local deposition efficiency, and the formation mechanism and structure-activity relationship of particles were revealed. The results showed that the spray drying samples were all in amorphous state, and the physicochemical properties of risperidone can be improved by the addition of CD. Compared to spray-dried pure RIS, spray-dried samples with CD addition had good fluidity (CI<30%) and more suitable particle sizes (35-55μm) for nasal delivery. When the mass ratio of drug excipients (RIS: CD) was 1:6, the deposition fraction in the olfactory region was 13.338%, indicating that this prescription has considerable potential for brain targeted delivery.