Asymmetric Allylic Substitution Reactions Based on Relay Catalysis

Abstract Transition-metal-catalyzed asymmetric allylic substitution reactions represent a hot research topic in the field of asymmetric synthesis, with significant progress having been made. Among diverse catalysis systems, relay catalysis enables sequential activation of multiple steps in one pot and the rapid construction of multiple chiral centers, providing a simple and powerful platform for organic synthesis. Recently, relay catalysis has been successfully applied to asymmetric allylic substitution reactions, and a variety of challenging transformations have been realized. This Short Review summarizes the related progress on asymmetric allylic substitution reactions based on relay catalysis over the last decade. 1 Introduction 2 The General Transformation Model 3 Allylation Relays Further Reaction 4 Initial Reaction Relays Allylation 5 Conclusion and Outlook