化学选择性
合成子
选择性
区域选择性
催化作用
反应性(心理学)
化学
背景(考古学)
戒指(化学)
组合化学
有机化学
医学
古生物学
替代医学
病理
生物
作者
Yaxin Zeng,Zhong–Tao Jiang,Ying Xia
摘要
Small-ring chemistry is a fascinating field in organic chemistry. gem-Difluorinated cyclopropanes, a unique class of cyclopropanes, have garnered significant interest due to their intrinsic high reactivity. In this context, gem-difluorinated cyclopropanes have been extensively investigated as fluoroallylic synthons in Pd-catalyzed ring-opening/cross-coupling reactions for the synthesis of monofluoroalkenes with linear or branched selectivity. In contrast, Rh-catalysis has revealed diverse selectivity in the reaction of gem-difluorinated cyclopropanes, such as regioselectivity, enantioselectivity, and chemoselectivity. This feature article aims to summarize our efforts towards developing Rh-catalyzed reactions of gem-difluorinated cyclopropanes, briefly discussing the design, selectivity, reaction mechanisms and future research prospects.
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