生物
计算生物学
转录组
维管植物
神经科学
植物发育
功能(生物学)
细胞
电池类型
细胞生物学
基因表达
遗传学
基因
生态学
物种丰富度
作者
Claudia von der Mark,Max Minne,Bert De Rybel
标识
DOI:10.1016/j.pbi.2024.102526
摘要
Vascular cells form a highly complex and heterogeneous tissue. Its composition, function, shape, and arrangement vary with the developmental stage and between organs and species. Understanding the transcriptional regulation underpinning this complexity thus requires a high-resolution technique that is capable of capturing rapid events during vascular cell formation. Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) approaches provide powerful tools to extract transcriptional information from these lowly abundant and dynamically changing cell types, which allows the reconstruction of developmental trajectories. Here, we summarize and reflect on recent studies using single-cell transcriptomics to study vascular cell types and discuss current and future implementations of sc/snRNA-seq approaches in the field of vascular development.
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