光动力疗法
材料科学
卟啉
胶质母细胞瘤
纳米颗粒
癌症研究
纳米技术
生物医学工程
光化学
医学
有机化学
化学
作者
Y.J. Chen,Yuxiao Ma,Shi Kai-quan,Huan Chen,Xiang Han,Chenxuan Wei,Yingqi Lyu,Yukun Huang,Renhe Yu,Yun Su,Qing Song,Jiyao Jiang,Junfeng Feng,Yingying Lin,Jun Chen,Hongzhuan Chen,Gang Zheng,Xiaoling Gao,Gan Jiang
标识
DOI:10.1002/adma.202307454
摘要
Abstract The dismal prognosis for glioblastoma multiform (GBM) patients is primarily attributed to the highly invasive tumor residual that remained after surgical intervention. The development of precise intraoperative imaging and postoperative residual removal techniques will facilitate the gross total elimination of GBM. Here, we developed a self‐disassembling porphyrin lipoprotein‐coated calcium peroxide nanoparticles (PLCNP) to target GBM via macropinocytosis, allowing for fluorescence‐guided surgery of GBM and improving photodynamic treatment (PDT) of GBM residual by alleviating hypoxia. By reducing self‐quenching and enhancing lysosome escape efficiency, the incorporation of calcium peroxide (CaO 2 ) cores in PLCNP amplified the fluorescence intensity of porphyrin‐lipid. Furthermore, the CaO 2 core has diminished tumor hypoxia and improved the PDT efficacy of PLCNP, enabling low‐dose PDT and reversing tumor progression induced by hypoxia aggravation following PDT. Taken together, this self‐disassembling and oxygen‐generating porphyrin‐lipoprotein nanoparticle may serve as a promising all‐in‐one nanotheranostic platform for guiding precise GBM excision and empowering post‐operative PDT, providing a clinically applicable strategy to combat GBM in a safe and effective manner. This article is protected by copyright. All rights reserved
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