非酒精性脂肪肝
内科学
医学
甘油三酯
脂肪肝
十五酸
代谢综合征
地中海饮食法
随机对照试验
内分泌学
脂肪酸
胆固醇
生理学
生物
肥胖
疾病
生物化学
作者
Yu Chung Chooi,Qinze Arthur Zhang,Faidon Magkos,Maisie Ng,Navin Michael,Xueying Wu,Vera Sergeyevna Brok Volchanskaya,Xianning Lai,Elvy Riani Wanjaya,Untzizu Elejalde,Chun Yan Goh,Choon Hwai Yap,Long Hui Wong,Kevin Lim,S. Sendhil Velan,Jadegoud Yaligar,Mark Muthiah,Yap Seng Chong,Evelyn Xiu Ling Loo,Johan G. Eriksson,Kah‐Leong Lim,Mabel Shu Fung Kouk,Eric Chong,Munirah Abd Gani,Lisha Li,Vicky Tay,Yeshe Manuel Kway,Mukkesh Kumar,Suresh Anand Sadananthan,Kah-Lin Khoo,Deborah Koh,Raymond Boon Tar Lim,Kang Chen,Kwang Li Sin,Jun Wei Lim
标识
DOI:10.1016/j.ajcnut.2023.11.013
摘要
Weight loss is the most effective treatment for nonalcoholic fatty liver disease (NAFLD). There is evidence that the Mediterranean diets rich in unsaturated fatty acids and fiber have beneficial effects on weight homeostasis and metabolic risk factors in individuals with NAFLD. Studies have also shown that higher circulating concentrations of pentadecanoic acid (C15:0) are associated with a lower risk for NAFLD.To examine the effects of a Mediterranean-like, culturally contextualized Asian diet rich in fiber and unsaturated fatty acids, with or without C15:0 supplementation, in Chinese females with NAFLD.In a double-blinded, parallel-design, randomized controlled trial, 88 Chinese females with NAFLD were randomly assigned to 1 of the 3 groups for 12 wk: diet with C15:0 supplementation (n = 31), diet without C15:0 supplementation (n = 28), or control (habitual diet and no C15:0 supplementation, n = 29). At baseline and after the intervention, body fat percentage, intrahepatic lipid content, muscle and abdominal fat, liver enzymes, cardiometabolic risk factors, and gut microbiome were assessed.In the intention-to-treat analysis, weight reductions of 4.0 ± 0.5 kg (5.3%), 3.4 ± 0.5 kg (4.5%), and 1.5 ± 0.5 kg (2.1%) were achieved in the diet-with-C15:0, diet without-C15:0, and the control groups, respectively. The proton density fat fraction (PDFF) of the liver decreased by 33%, 30%, and 10%, respectively. Both diet groups achieved significantly greater reductions in body weight, liver PDFF, total cholesterol, gamma-glutamyl transferase, and triglyceride concentrations compared with the control group. C15:0 supplementation reduced LDL-cholesterol further, and increased the abundance of Bifidobacterium adolescentis. Fat mass, visceral adipose tissue, subcutaneous abdominal adipose tissue (deep and superficial), insulin, glycated hemoglobin, and blood pressure decreased significantly in all groups, in parallel with weight loss.Mild weight loss induced by a Mediterranean-like diet adapted for Asians has multiple beneficial health effects in females with NAFLD. C15:0 supplementation lowers LDL-cholesterol and may cause beneficial shifts in the gut microbiome.This trial was registered at the clinicaltrials.gov as NCT05259475.