Self-assembled multifunctional Prussian blue analogues nanocomposite for MRI-guided multimodal therapy for breast cancer

Integration of multimodal imaging and therapies into one nanoplatform holds great promise to overcome the drawbacks of conventional single-modal cancer therapy. Designing multifunctional nanocomposite by self-assembled strategy with integration of various functional components into one platform is promising for effective breast cancer therapy. Herein, a L-arginine embedded Prussian blue analogue@polypyrrole@manganese oxide (PBA@PPy@MnO2) multifunctional nanocomposite was constructed by a facile self-assembled method, which could be used as an effective nanoplatform for magnetic resonance imaging (MRI) guided multimodal therapy for breast cancer. Various properties such as enhanced MRI and catalytic capacity from PBA and MnO2, photothermal conversion performance from PPy, and NO generation capacity from Arg were integrated into one nanocomposite. In vitro and vivo experiments, satisfactory anti-cancer efficiency was observed in PBA@PPy@MnO2@Arg nanoplatform under near-infrared irradiation (NIR) due to the combined effect between chemodynamic therapy (CDT), photothermal therapy (PTT), and gas therapy (GT). This work will pave a new avenue for the construction of multifunctional nanoplatforms and overcome the inherit poor photothermal and MRI activities limitations of Prussian blue analogue in biomedical field.