间充质干细胞
血管翳
类风湿性关节炎
医学
间质细胞
软骨
癌症研究
免疫学
炎症
血管生成
发病机制
关节炎
病理
解剖
作者
Estera Bakinowska,Aleksandra Wiktoria Bratborska,Kajetan Kiełbowski,Maciej Ćmil,Wojciech Jerzy Biniek,Andrzej Pawlik
出处
期刊:Cells
[Multidisciplinary Digital Publishing Institute]
日期:2024-05-25
卷期号:13 (11): 915-915
被引量:6
标识
DOI:10.3390/cells13110915
摘要
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI