A comparison of methods to harmonize cortical thickness measurements across scanners and sites
计算机科学
地质学
遥感
计算机视觉
作者
Delin Sun,Gopalkumar Rakesh,Courtney C. Haswell,Mark Logue,C. Lexi Baird,Erin N. O’Leary,Andrew S. Cotton,Hong Xie,Marijo Tamburrino,Tian Chen,Emily L. Dennis,Neda Jahanshad,Lauren E. Salminen,Sophia I. Thomopoulos,Faisal Rashid,Christopher R. K. Ching,Saskia B. J. Koch,Jessie L. Frijling,Laura Nawijn,Mirjam van Zuiden
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LME