Vascular Smooth Muscle TRPV4 (Transient Receptor Potential Vanilloid Family Member 4) Channels Regulate Vasoconstriction and Blood Pressure in Obesity

Our data identify TRPV4_SMC as a regulator of vascular contraction in both physiological states and pathologically obese mice. TRPV4_SMC contributes to the ontogeny of vasoconstriction and hypertension induced by TRPV4_SMC over-expression in obese mice mesenteric artery.