半乳糖凝集素
糖复合物
生物医学
半乳糖凝集素-3
糖基化
细胞粘附
计算生物学
生物化学
半乳糖凝集素-1
凝集素
生物
细胞生物学
聚糖
糖蛋白
化学
糖生物学
细胞
生物信息学
免疫学
作者
Dominic Laaf,Pavla Bojarová,Lothar Elling,Vladimír Křen
标识
DOI:10.1016/j.tibtech.2018.10.001
摘要
Cellular communication events are mediated by interactions between cell-surface sugars and lectins, which are carbohydrate-binding proteins. Galectins are β-galactosyl-binding lectins that bridge molecules by their sugar moieties, forming a signaling and adhesion network. Severe changes in glycosylation and galectin expression accompany major processes in oncogenesis, cardiovascular disorders, and other pathologies, making galectins attractive therapeutic targets. Here we discuss advanced strategies of chemo-enzymatic carbohydrate synthesis for creating lead glycomimetics and (neo-)glycoconjugates for galectin-1 and -3 targeting in biomedicine and biotechnology. We will describe the challenges and bottlenecks on the route into biomedical and biotechnological practice and present the first clinical candidates. The coming era will see an exciting translation of selective well-defined high-affinity galectin ligands from bench to bedside.
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