Phoma公司
乙酸乙酯
癌细胞系
立体化学
杂色曲霉素
LNCaP公司
化学
真菌
聚酮
高分辨率
生物
植物
癌细胞
有机化学
癌症
生物合成
酶
地质学
真菌毒素
遥感
遗传学
作者
Hyeri Ku,Jiyun Baek,Ki Sung Kang,Sang Eun Shim
标识
DOI:10.1080/14786419.2021.2022663
摘要
A new oxazole-type compound (1), named macrooxazole E, and three known macrooxazoles A-C (2-4), were isolated from ethyl acetate (EtOAc) extracts of Phoma sp. JS0228 cultures, an endophytic fungus of Morus alba (M. alba). Structures of the isolated compounds were determined using spectroscopic methods, such as 1 D- and 2 D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Macrooxazole E (1) differed from macrooxazole C only in the presence of methyl carboxylate instead of free carboxylic acid. Macrooxazole C showed moderate anti-proliferative activities against human breast cancer (MCF-7) and prostate cancer (LNCaP) cell lines with IC50 values of 0.29 mM and 0.36 mM, respectively. This study presents the possibility of the endophytic fungus Phoma sp. JS0228 to produce new bioactive natural compounds.
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