纳米医学
超分子化学
化学
癌症研究
免疫原性细胞死亡
免疫检查点
癌症免疫疗法
喜树碱
免疫疗法
组合化学
免疫系统
纳米技术
材料科学
生物化学
医学
纳米颗粒
免疫学
有机化学
晶体结构
作者
Kai Yang,Shaolong Qi,Xinyang Yu,Bing Bai,Xueyan Zhang,Zhengwei Mao,Feihe Huang,Guocan Yu
标识
DOI:10.1002/ange.202203786
摘要
Abstract Supramolecular nanomedicines have shown great merits in cancer therapy, but their clinical translation is hampered by monotonous therapeutic modality and unsatisfactory antitumor performance. Herein, a hybrid supramolecular polymeric nanomedicine ( SNPs ) is developed based on β‐cyclodextrin/camptothecin (CPT) host−guest molecular recognition and iron‐carboxylate coordination. Iron ions stabilizing SNPs catalyze the conversion of intracellular hydrogen peroxide into highly toxic hydroxyl radical through a Fenton reaction, which further cleaves the thioketal linker of the supramolecular monomer to release potent CPT, thus amplifying the therapeutic efficacy by combining chemodynamic therapy and chemotherapy. The combination therapy stimulates antitumor immunity and promotes intratumoral infiltration of cytotoxic T lymphocytes by triggering immunogenic cell death. In synergy with PD‐L1 checkpoint blockade, SNPs enables enhanced immune therapy and a long‐term tumor remission.
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