活性氧
单线态氧
激进的
光催化
超氧化物
光化学
氧气
生物膜
硼
纳米片
材料科学
羟基自由基
化学
纳米技术
化学工程
细菌
催化作用
有机化学
生物化学
酶
遗传学
工程类
生物
作者
Bei Ran,Lei Ran,Jungang Hou,Xiaojun Peng
出处
期刊:Small
[Wiley]
日期:2022-03-24
卷期号:18 (17)
被引量:10
标识
DOI:10.1002/smll.202107333
摘要
Photocatalytic therapy is an alternative antibacterial pathway but most photocatalysts are limited by light absorption, charge transfer and insufficient production of reactive oxygen species (ROS). Herein, the authors utilize boron doped niobic acid nanosheets (B-HNbO3 NSs) as a superior photocatalytic antibacterial platform. The experimental results and density functional theory (DFT) confirm that superior photocatalytic therapy activity is mainly due to boron doping, which not only promotes the generation and separation of electrons and holes, but also enhances the adsorption of water and oxygen molecules on B-HNbO3 NSs. Consequently, multiple ROS including hydroxyl radicals (•OH), superoxide radicals (•O2- ), and singlet oxygen (1 O2 ) are generated under light irradiation, resulting in outstanding bacterial killing ability of B-HNbO3 NSs. Besides, oxygen is produced during the therapy process, thus alleviating the inflammatory response caused by hypoxia. Furthermore, molecular dynamics (MD) simulations verify that the nanosheet structure makes it possess strong electrostatic attraction for bacterial cell membranes, leading to physical insertion and damage to bacterial cells. Therefore, bactericidal rates for four types of bacteria are all more than 99%, proving its excellent and broad-spectrum antibacterial capacity. Moreover, B-HNbO3 NSs could be applied to treat biofilm-coated medical devices in vivo, suggesting its possibility in practical application.
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