P483. Perturbation of Cell-Subtype Specific Active Kinome Networks in Schizophrenia

Schizophrenia is an illness with significant consequences for patients and their families. Since the disease affects executive function, the Dorsolateral Pre-frontal Cortex (DLPFC) has been an area of interest. We previously reported perturbed protein kinase activity of kinases, including AKT, in postmortem brain samples of patients with schizophrenia. We are now extending this hypothesis to the cell level, with a focus on frontal cortical pyramidal neurons.