Modification of hyaluronic acid and chitosan, aimed at developing hydrogels for ophthalmology

Modification of hyaluronic acid and chitosan with the aim of preparing hydrogels based on them was performed. The formation of a covalent bond between mitomycin C and hyaluronic acid modified with epichlorohydrin was demonstrated. Hydrogels based on hyaluronic acid dialdehyde and chitosan modified with succinic anhydride were prepared. The degree of modification and concentration of the polymers influence the gelation process. Prolonged release of mitomycin C from the hydrogel obtained was revealed.