解旋酶
生物
RNA解旋酶A
基因
遗传学
核糖核酸
计算生物学
作者
Mohamed Abdelhaleem,Lois J. Maltais,Hester Wain
出处
期刊:Genomics
[Elsevier]
日期:2003-06-01
卷期号:81 (6): 618-622
被引量:144
标识
DOI:10.1016/s0888-7543(03)00049-1
摘要
Nucleic acid helicases are characterized by the presence of the helicase domain containing eight motifs. The sequence of the helicase domain is used to classify helicases into families. To identify members of the DEAD and DEAH families of human RNA helicases, we used the helicase domain sequences to search the nonredundant peptide sequence database. We report the identification of 36 and 14 members of the DEAD and DEAH families of putative RNA helicases, including several novel genes. The gene symbol DDX had been used previously for both DEAD- and DEAH-box families. We have now adopted DDX and DHX symbols to denote DEAD- and DEAH-box families, respectively. Members of human DDX and DHX families of putative RNA helicases play roles in differentiation and carcinogenesis.
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