试剂
溴
卤化
化学
溴化物
溴酸盐
有机化学
亚甲基
酚类
催化作用
苯
作者
Subbarayappa Adimurthy,G. Ramachandraiah,Ashutosh V. Bedekar,Sudip Kumar Ghosh,Brindaban C. Ranu,Pushpito K. Ghosh
出处
期刊:Green Chemistry
[The Royal Society of Chemistry]
日期:2006-01-01
卷期号:8 (10): 916-916
被引量:109
摘要
Facile bromination of various organic substrates has been demonstrated with a 2 : 1 bromide:bromate reagent prepared from the alkaline intermediate of the conventional bromine recovery process. The reagent is acidified in situ to generate HOBr as the reactive species, which effects bromination. Aromatic substrates that have been successfully brominated under ambient conditions without use of any catalyst include phenols, anilines, aromatic ethers and even benzene. Non-aromatic compounds bearing active methylene group were monobrominated selectively with the present reagent and olefinic compounds were converted into the corresponding bromohydrins in moderate yields. By obtaining the present reagent from the liquid bromine precursor, the twin advantages of avoiding liquid bromine and producing the reagent in a cost-effective manner are realised. When coupled with the additional advantage of high bromine atom efficiency, the present protocol becomes attractive all the way from "cradle to grave".
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