Optically active perfluoro-2-propoxypropionic acid: A new chiral reagent for 19F NMR study

Abstract Perfluoro-2-propoxypropionic acid, which was prepared by the anionic dimerization of hexafluoro-1,2-epoxypropane, was optically resolved via diastereomeric salt formation with chiral amines. The optically pure (+) and (−) perfluoro-2-propoxypropionic acids thus obtained were found to be a convenient chiral reagent for determining enantiomeric compositions of α-amino acids by means of 19 F nmr analysis.