细胞色素b5
细胞色素P450还原酶
黄蛋白
还原酶
生物化学
细胞色素b
基因亚型
黄素腺嘌呤二核苷酸
高铁血红蛋白
化学
细胞色素c氧化酶
细胞色素
细胞色素c
生物
血红蛋白
辅酶Q-细胞色素c还原酶
酶
辅因子
基因
线粒体
线粒体DNA
作者
Fatemeh Elahian,Zargham Sepehrizadeh,Bahareh Moghimi,Seyed Abbas Mirzaei
标识
DOI:10.3109/07388551.2012.732031
摘要
Cytochrome b5 reductase is a flavoprotein that is produced as two different isoforms that have different localizations. The amphipathic microsomal isoform, found in all cell types with the exception of erythrocytes, consists of one hydrophobic membrane-anchoring domain and a larger hydrophilic flavin catalytic domain. The soluble cytochrome b5 reductase isoform, found in human erythrocytes, is a truncated protein that is encoded by an alternative transcript and consists of the larger domain only. Cytochrome b5 reductase is involved in the transfer of reducing equivalents from the physiological electron donor, NADH, via an FAD domain to the small molecules of cytochrome b5. This protein has received much attention from researchers due to its involvement in many oxidation and reduction reactions, such as the reduction of methemoglobin to hemoglobin. Autosomal cytochrome b5 reductase gene deficiency manifests with the accumulation of oxidized Fe+3 and recessive congenital methemoglobinemia in humans. In this article, we provide a comprehensive overview of the structure and function of cytochrome b5 reductase from different eukaryotic sources and its potential use in the food industry, biosensor, and diagnostic areas.
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