神经保护
细胞粘附分子
缺血
药理学
再灌注损伤
医学
冲程(发动机)
粘附
细胞粘附
脑梗塞
化学
细胞
生物化学
内科学
免疫学
工程类
有机化学
机械工程
作者
Yufang Cheng,Han‐Ting Zhang,Lin Sun,Shu Guo,Shi Ouyang,Yanjun Zhang,Jiang Xu
出处
期刊:Brain Research
[Elsevier]
日期:2006-09-01
卷期号:1110 (1): 193-200
被引量:68
标识
DOI:10.1016/j.brainres.2006.06.065
摘要
Previous studies have demonstrated that polydatin, a crystal component extracted from the root stem of the perennial herbage Polygonum Cuspidatum Sieb.et Zucc, exerts a neuroprotective effect on cerebral injury induced by ischemia/reperfusion. To investigate the possible mechanism of this action, we determined the effects of polydatin on the expression of cell adhesion molecules (CAMs) after ischemia-induced cerebral injury. Rats were treated with polydatin (i.v.) immediately after the operation of middle cerebral artery occlusion (MCAO) for 1 h. It was found that polydatin improved neurological deficits and reduced the volume of brain infarction. In addition, polydatin decreased the levels of CAMs relative to the control (MCAO alone); these included intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, L-selectin and Integrins. These results suggest that polydatin exerts protective effects likely via inhibition of the expression of various CAMs; polydatin may be a potential agent for treatment of brain injury associated with stroke.
科研通智能强力驱动
Strongly Powered by AbleSci AI