两亲性
氢键
化学
聚合物
Zeta电位
聚氨酯
高分子化学
动态光散射
水溶液
疏水效应
溶剂
聚合物囊泡
化学工程
荧光
表面电荷
变性(裂变材料)
有机化学
核化学
共聚物
分子
纳米颗粒
物理化学
物理
量子力学
工程类
作者
Tathagata Mondal,Krishna Dan,Jolly Deb,Siddhartha S. Jana,Suhrit Ghosh
出处
期刊:Langmuir
[American Chemical Society]
日期:2013-05-22
卷期号:29 (22): 6746-6753
被引量:43
摘要
We have reported synthesis and vesicular assembly of a novel amphiphilic polyurethane with hydrophobic backbone and hydrophilic pendant carboxylic acid groups which were periodically grafted to the backbone via a tertiary amine group. In aqueous medium the polymer chain adopted a folded conformation which was stabilized by intrachain H-bonding among the urethane groups. Such a model was supported by concentration and solvent-dependent FT-IR, powder XRD, and urea-mediated “denaturation” experiments. Folded polymer chains further formed vesicular assembly which was probed by dynamic light scattering, TEM, AFM, SEM, and fluorescence microscopic studies, and dye encapsulation experiments. pH-dependent DLS and fluorescence microscopic studies revealed stable polymersome in entire tested pH window of 3.5–11.0. Zeta potential measurements showed a negatively charged surface in basic pH while a charge-neutral surface in neutral and acidic pH. MTT assay with CHO cell line indicated good cell viability.
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