炎症体
促炎细胞因子
免疫学
NALP3
半胱氨酸蛋白酶1
疾病
医学
炎症
阿纳基纳
细胞因子
病理
作者
Takashi Satoh,Atsushi Otsuka,Emmanuel Contassot,Lars E. French
出处
期刊:Immunotherapy
[Future Medicine]
日期:2015-03-01
卷期号:7 (3): 243-254
被引量:58
摘要
The bioactive form of IL-1β, a key immunoregulatory and proinflammatory cytokine, is produced by the inflammasome - a caspase-1 activating molecular platform - in response to selected danger-associated molecular patterns and pathogen-associated molecular patterns. Advances in understanding the role of IL-1β in inflammatory conditions has resulted in IL-1β becoming a therapeutic target for a number of inflammatory diseases beyond the rare monogenic autoinflammatory diseases characterized by aberrant inflammasome function and enhanced bioactive IL-1β production. In the monogenic autoinflammatory diseases known as cryopyrin-associated periodic syndromes, neutralization of IL-1β results in a rapid and sustained reduction in disease severity without severe side effects, which has consequently driven off-label applications of IL-1β-targeted therapy in other inflammatory diseases. This review summarizes inflammatory diseases for which accumulating evidence suggests a therapeutic potential for IL-1β antagonists.
科研通智能强力驱动
Strongly Powered by AbleSci AI