神经化学
多巴胺
地唑西平
多巴胺能
化学
纹状体
神经递质
内科学
内分泌学
谷氨酸受体
NMDA受体
3,4-二羟基苯乙酸
药理学
中枢神经系统
医学
受体
高香草酸
生物化学
血清素
作者
Mónica Padilla-de la Torre,Javier Franco-Pérez,Abel Santamarı́a,Sonia Galvan,Edith González,Carlos Paz
标识
DOI:10.1196/annals.1432.038
摘要
Alterations in motor activity related to dopamine changes in some brain regions have been described as consequences of the modifications produced by systemic administration of MK-801 (a noncompetitive NMDA receptor antagonist) in rats. Acetaldehyde (ACH), the main metabolite of ethanol, has been implicated in different alterations in the central nervous system after ethanol ingestion. ACH might exert some control on dopaminergic transmission through the formation of other compounds with dopamine, which eventually may modify dopamine content and its metabolism. In order to evaluate such a hypothesis, we used Wistar rats in the present study to evaluate the effect of ACH on locomotor alterations and dopamine metabolism changes induced by MK-801. Our results show that the MK-801-treated group had a significant increase in locomotor activity. In contrast, we did not find significant differences in locomotion tests after ACH administration. However, the group to which both drugs were administered showed a significant decrease in locomotor activity compared with those given MK-801 alone. Neurochemical analysis showed an increase in dopamine content in the striatum and frontal cortex after MK-801 administration, however; the increase was reversed by giving 200 mg/kg of ACH. These results indicate that ACH can produce an antagonic-like effect on locomotor alterations and dopamine content changes induced by MK-801, thus modulating the MK-801-induced hyperlocomotion by interfering with dopamine metabolism.
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