被盖腹侧区
多巴胺能
前肢
多巴胺
安非他明
刺激
医学
神经科学
氧化多巴胺
麻醉
根切断术
背
心理学
解剖
黑质
作者
Eugen Gorea,Marie-Christine Lombard
标识
DOI:10.1016/0304-3940(84)90291-x
摘要
Partial rhizotomy (section of dorsal roots C5 to Th 1 included) leads to abnormal mutilating behavior in the rat, presumably due to pain sensation in the deafferented limb. As dopamine (DA) has been shown to play a role in analgesia, destruction and stimulation of the ventral tegmental area (VTA) were used to check whether they induced an increase or a decrease in the mutilating behavior respectively. Destruction of DA neurons located in the VTA was performed by local administration of 6-hydroxydopamine whereas activation was achieved either by imposed electrical stimulation or by chronic oral administration of D-amphetamine sulfate. These 3 treatments accelerated the onset of the mutilating behavior and induced an extension of the mutilating wounds, D-amphetamine sulfate producing the most pronounced acceleration in their development. The results obtained after destruction of DA-VTA neurons fit well with the working hypothesis. The increase of the mutilating behavior rather than a decrease subsequent to the other treatments could have been caused by the hyperactivity and increase of chewing behavior induced by the less specific stimulating techniques.
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