Parkinson’s Disease

This chapter introduces the basic pathological hallmarks and general risk factors associated with Parkinson's Disease (PD). It then briefly introduces genetic and environmental factors linked to PD. The classic and emerging animal models used to study PD pathogenesis are included to discuss their relative strengths and weaknesses and biological plausibility as they relate to PD. Finally, new alternative species models are discussed as a platform for exploring gene–environment interactions in a high-throughput manner. Emerging areas of investigation and future directions in relating genetic susceptibility and environmental exposures finishes the chapter.