The relationship between t and H-2 complexes in wild mice: I. The H-2 haplotypes of 20 t-bearing strains

SUMMARY Twenty t haplotypes were extracted from wild mice captured at several locations in Europe, Israel, North Africa, and South America. The haplotypes were designated t Tuw1 through t Tuw20 . The H-2 haplotypes of the lines were defined using antisera and monoclonal antibodies specific for private antigenic determinants controlled by known H-2 alleles and by antisera produced using the new t lines as donors. The t Tuw haplotypes fall into four groups according to the H-2 haplotype associated with them. Haplotypes t Tuw10 through t Tuw18 are associated with H-2 W30 , previously found to be linked with haplotypes of the t w1 group. Haplotypes t Tuw1 through t Tuw6 are associated with a new H-2 haplotype, H-2 w36 , characterized by the determinant H-2.107. Haplotypes t Tuw7 through t Tuw9 are associated with another new H-2 haplotype, H-2 w37 , characterized by determinants H-2.108 and H-2.111. And finally, haplotypes t Tuw19 and t Tuw20 are associated with yet another new H-2 haplotype, H-2 w38 , characterized by determinants H-2.33 and H-2.109. These findings suggest that the t polymorphism might be more extensive and more intricate than it was previously thought to be and that at least some of the t -associated H-2 haplotypes, and probably also the t haplotypes themselves, are related to one another in their origin.