mTORC1型
嘌呤
细胞生物学
生物化学
抄写(语言学)
合成代谢
蛋白质生物合成
泛素连接酶
生物
嘌呤代谢
化学
信号转导
酶
泛素
基因
PI3K/AKT/mTOR通路
语言学
哲学
作者
Issam Ben-Sahra,Gerta Hoxhaj,Stéphane J. H. Ricoult,John M. Asara,Brendan D. Manning
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-02-12
卷期号:351 (6274): 728-733
被引量:579
标识
DOI:10.1126/science.aad0489
摘要
Controlling supplies for DNA and RNA synthesis The mTORC1 protein kinase complex regulates anabolic metabolism and coordinates cellular signals that promote growth with availability of required precursor metabolites. Signaling through mTORC1 controls pyrimidine synthesis. Ben-Sahra et al. found that mTORC1 also functions by a different mechanism to regulate purine biosynthesis, thus generating precursors for the synthesis of RNA and DNA (see the Perspective by Ma and Jones). Signaling by mTORC1 caused accumulation of the transcription factor ATF4, which enhances production of the enzyme methylenetetrahydrofolate dehydrogenase 2, thus leading to increased production of the purine nucleotides needed for cell growth. Science , this issue p. 728 ; see also p. 670
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