寡核苷酸
计算生物学
补语(音乐)
补体系统
替代补体途径
机制(生物学)
生物
药理学
医学
免疫学
生物化学
表型
DNA
基因
认识论
哲学
抗体
互补
作者
Scott P. Henry,Rosanne Séguin,Joy A. Cavagnaro,Cindy L. Berman,Jeff Tepper,Douglas J. Kornbrust
出处
期刊:Nucleic Acid Therapeutics
[Mary Ann Liebert]
日期:2016-08-01
卷期号:26 (4): 210-215
被引量:31
标识
DOI:10.1089/nat.2015.0593
摘要
This article provides an overview of the discussions held by the Immunomodulatory Subcommittee of the Oligonucleotide Safety Working Group on complement activation induced by oligonucleotides, most notably the phosphorothioate-containing oligonucleotides. Alternative complement pathway activation in monkeys is a common effect of single-stranded phosphorothioate backbone oligonucleotides in toxicology studies. This article discusses the mechanism for activation, general investigational strategy, and the impact of various chemical modifications. The goal is to provide the best practice approach to characterizing this effect, understanding the implication of the species specificity, and the interpretation of clinical relevance.
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