Glucose assay based on a fluorescent multi-hydroxyl carbon dots reversible assembly with phenylboronic acid brush grafted magnetic nanoparticles

A novel composite fluorescent probe was synthesized by assembling multi-hydroxyl carbon dots (CDs) on magnetic nanoparticles modified with phenylboronic acid (PBA) molecular brush by a reversible dynamic covalent bond. Subsequently, the composite fluorescent probe was used for glucose determination, demonstrating that the so-prepared nanoparticles mask the fluorescence of the multi-hydroxyl CDs due to the light adsorption of the black magnetic nanoparticles. The fluorescence can be recovered in the presence of glucose in the solution due to the release of the multi-hydroxyl CDs. The fluorescence intensity of the released multi-hydroxyl CDs exhibits a relatively good linear relationship with the concentration of glucose. The results of the glucose assay show that the composite fluorescent probe possesses high sensitivity and a wide linear response range from 0.2 to 20 mM of glucose, confirming to be promising sensor glucose non-enzymatic detection.