鼻咽癌
岩石1
转移
癌症研究
癌
下调和上调
医学
肿瘤科
内科学
生物
细胞生物学
癌症
信号转导
基因
生物化学
放射治疗
罗亚
作者
Duan Zn,Dong Cg,Liu Jh
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2020-12-01
被引量:5
摘要
Objective Nasopharyngeal carcinoma (NPC) is one of the most ordinary head and neck tumors. This study aims to uncover the role of circ-ABCB10 functions in the progression of NPC. Patients and methods The circ-ABCB10 expression was detected in paired NPC patients' tissue samples and cell lines. The role of circ-ABCB10 in NPC proliferation was identified through proliferation assay, Ethynyl deoxyuridine (EdU) assay and colony formation assay. Next, the role of circ-ABCB10 in NPC metastasis was measured through wound healing assay and transwell assay. Finally, the underlying mechanism was further uncovered through Western blot assay and real-time quantitative polymerase chain reaction (RT-qPCR). Results It was found that circ-ABCB10 expression was significantly higher in NPC tissues than that in adjacent samples. In addition, cell proliferation, migration and invasion of NPC were promoted through overexpression of circ-ABCB10 in vitro. Results of further experiments revealed that ROCK1 was upregulated via overexpression of circ-ABCB10 in NPC. Conclusions This study indicated that circ-ABCB10 promoted NPC cell proliferation and metastasis via upregulating ROCK1 in vitro.
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