视黄醇X受体
维甲酸
维甲酸
核受体
生物
维甲酸受体
受体
肝星状细胞
贝沙罗汀
细胞生物学
生物化学
转录因子
内分泌学
基因
作者
Baixue Li,Shi–Ying Cai,James L. Boyer
标识
DOI:10.1016/j.bbadis.2021.166085
摘要
Activated by retinoids, metabolites of vitamin A, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) play important roles in a wide variety of biological processes, including embryo development, homeostasis, cell proliferation, differentiation and death. In this review, we summarized the functional roles of nuclear receptor RAR/RXR heterodimers in liver physiology. Specifically, RAR/RXR modulate the synthesis and metabolism of lipids and bile acids in hepatocytes, regulate cholesterol transport in macrophages, and repress fibrogenesis in hepatic stellate cells. We have also listed the specific genes that carry these functions and how RAR/RXR regulate their expression in liver cells, providing a mechanistic view of their roles in liver physiology. Meanwhile, we pointed out many questions regarding the detailed signaling of RAR/RXR in regulating the expression of liver genes, and hope future studies will address these issues.
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