An anti-disturbance control problem is investigated in this paper. The disturbance observer plus back-stepping (DOPBS) control scheme is proposed for a class of strict-feedback nonlinear systems with derivative-bounded disturbances. A nonlinear disturbance observer is designed to estimate the derivative-bounded disturbances. By combining the disturbance observer with back-stepping method, the DOPBS controller is designed to reject and attenuate the disturbances. Stability analysis proves that all the signals in the the closed-loop system are uniformly ultimately bounded (UUB). Finally, simulation examples demonstrate the feasibility and effectiveness of the proposed approach compared with existing methods.