DNA断裂
DNA
染色质
碎片(计算)
计算生物学
胎儿游离DNA
生物
DNA测序
分子生物学
液体活检
数字聚合酶链反应
细胞生物学
化学
遗传学
细胞凋亡
基因
聚合酶链反应
程序性细胞死亡
胎儿
癌症
生态学
产前诊断
怀孕
出处
期刊:Current trends in clinical & medical sciences
[Iris Publishers LLC]
日期:2020-01-29
卷期号:1 (4)
被引量:1
标识
DOI:10.33552/ctcms.2020.01.000519
摘要
High-throughput sequencing of circulating cell-free DNA (cfDNA) as liquid biopsy has revolutionized tumor genome profiling by providing a more accurate, longitudinal, real-time and non-invasive mean for precision and personalized medicine. Current knowledge on cfDNA characteristics revealed that it exists mainly as double-stranded molecules, resulting from biological fragmentation into both short (<1 kb) and long segments (>10 kb) [1,2]. Short fractions are mostly derived from apoptosis via the activation of cellular endonucleases leading to the cleavage of chromatin DNA into inter-nucleosomal fragments [3], whereas necrosis generates relatively long fragments of DNA.
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