The Effects of Bai Yu ginkgolide Injection on Platelet aggregation in rabbits

Aim:To observe the effects of Bai Yu ginkgolide injection on platelet aggregation,ultra structure and PF-4 and β-TG level in rabbits.Methods:Japanese big ear rabbits were randomly divided into Bai Yu ginkgolide Injection Low dose group,middle dose group,high dose group,and saline group,all of which were given corresponding treatment.In vivo experiments,when PAF induced platelet aggregation,platelet aggregation,ultra structure and PF-4 and β-TG level were observed.Results:Bai Yu ginkgolide injection could inhibit plate aggregation,reduce the number of aggregation type platelets and make fewer and shorter processes of dendritic platelets and reduce the level of PF-4 and β-TG significantly(P 0.01).Conclusion:Bai Yu ginkgolide injection could antagonism PAF-induced platelet aggregation,inhibit the activation of platelets,and is a kind of important anti platelet aggregation drug.