Objective:To improve the recognition of Paget's disease of the scrotum metastasized to multiple organs.Method:To report a case of Paget's disease of the scrotum metastasized to multiple organs and review the articles.Results:Paget's disease of the scrotum metastasized to multiple organs was a rare.Conclusion:Paget's disease of the scrotum metastasized to multiple organs is a rare.The early diagnosis and treatment are important.