Changes of serum soluble E-selectin and its significance in the patients with head injury

Objective To investigate the changes of serum soluble E-selectin (sES) in the patients following head injury. Methods sES was measured in 30 patients with Glasgow Coma Scale (GCS) between 3～8 and 25 patients with GCS between 9～15 within 12,24,48,72,96 hours after head injury by enzyme-linked immunosorbent assay (ELISA). The relationship between sES and Glasgow Outcome Scale (GOS) were studied. Results sES in the patients with GCS between 3～8 was the highest within 12 hours after head injury ( P 0.05), and it was still higher on the 4rd day after head injury (P 0.05). The outcome of the patients with sES 60 μg/L was poorer than that of the patients with sES 60 μg/L ( P 0.05). Conclusion Serum level of sE-selectin is elevated in the patients with head injury, which correlated with the outcome of the patients.