免疫学
细胞因子
免疫系统
生物
效应器
人口
T细胞
功能(生物学)
免疫
细胞生物学
细胞
医学
遗传学
环境卫生
作者
Fiona Powrie,Robert L. Coffman
出处
期刊:Immunology Today
[Elsevier]
日期:1993-06-01
卷期号:14 (6): 270-274
被引量:387
标识
DOI:10.1016/0167-5699(93)90044-l
摘要
CD4+ T cells, via the cytokines that they produce, play a pivotal role in the induction and regulation of cell-mediated and humoral immunity. Recently it has become clear that the CD4+ T-cell population is heterogeneous and that distinct CD4+ T-cell subsets, defined by their cytokine repertoire, regulate cell-mediated and humoral immune responses. Protective responses to pathogens are dependent on activation of the appropriate TH subset accompanied by its characteristic set of immune effector functions. Evidence to date suggests that the cytokines produced by the TH cells themselves are important regulators of TH subset activation and differentiation. Here, Fiona Powrie and Robert Coffman discuss how manipulation of the levels of these cytokines can be used to alter the balance of TH cell subsets and illustrate some clinical situations where this may be beneficial.
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